Nasal Drug Delivery Systems are the most effective and safest way of delivering Drug into body4/7/2022 Nasal Drug Delivery Systems are used to deliver medication to patients through the nose. These systems are designed to deliver medications in the nasal cavity for maximum drug absorption. Nasal Drug Delivery Systems are designed to mask the unpleasant taste and smell of drugs. They can be used both locally and systemically. Their growing importance has been fueled by several advantages. The nasal route is an attractive delivery method because it bypasses the first-pass metabolism of drugs in the gastrointestinal tract. Its direct connection to the brain makes nasal drug delivery a viable alternative to intravenous administration. It may even encourage the treatment of brain disorders. If successful, this technology may revolutionize the delivery of drugs. Many drugs have unpleasant taste and odor and a nasal drug delivery system can help mask these unpleasant effects. These devices are both systemically and locally applied, and have grown in popularity in the last five years. Bioadhesive polymers have been studied for their ability to adhere to the mucus membrane and spread over the nasal epithelium. These polymers have secondary chemical bonds with mucin molecules. Bioadhesive systems have been tested for the delivery of antibiotics, insulin, and scopolamine hydrochloride. In addition to these studies, several other Nasal Drug Delivery System have been developed. Another technique involving Nasal Drug Delivery is using hypergravity. When a drug is inhaled through the nasal cavity, it can enter the brainstem through the pons. The drugs then travel from the caudal to rostral regions of the brainstem. Hypergravity improves the absorption of polar drugs. RPMI 2650 cells or primary human nasal epithelial cells were exposed to a 10 x g hypergravitational environment for 20 min, and rested for 20 minutes after each exposure. Another potential method of drug delivery to the brain is the use of liposomes. These nanoparticles are made from phospholipids. They prevent rapid degradation through the blood-brain barrier (BBB) and are thus effective in the delivery of therapeutic drugs to the brain. The process also promotes the absorption of these drugs by the brain. Nasal drug absorption depends on several factors. Nasal blood flow, concentration of the drug, and excipient are all important. Other factors that affect absorption include nasal blood flow, mucociliary clearance, and the physical condition of the nose. If the drug drips out of the nose, it will not be absorbed properly and may reach the back of the throat. Mucociliary clearance also decreases the contact time of the drug with the nasal tissues. One way to increase drug delivery through this method is to use a nanostructured lipid carrier system. This carrier system contains duloxetine, which has anti-depressant properties. The system was developed by mixing melted solid lipid with an aqueous solution of surfactants. A biodistribution study has shown that DLX-NLC formulation effectively penetrates the BBB and maintains prolonged drug release at the target site. So these system are considered to be a better alternative to needle insertion.
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